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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6542822d2fb18022ab8937e3b1eb94706acf40aff4cd7eccb64a2df5e5c3d279' 
  AND token = '9+tdSWaKY7DRn2tdEcDavO3Ys/jd+9kbLsLQno2j+Ec=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}