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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd8d6d6050adee6c0be66ceba70b3dca0b89ca274ed3b720e40b00282a01feb26' 
  AND token = 'B5zFcsyxF4iz1MpFxgjeDGM7y5/xqbrUN2pUbW/cVOs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}