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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '149e291a9b4642d438efba1227eb4a2fd29acef60f43b16c9afe65be435e1703' 
  AND token = 'X26ivdrW6Qv3h2pPqddwbzyyHbDNC9OdDK0a6Z6bwq4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}