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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '54c8b23fcddee6c33949503bf45ea9f489c120b80cb1729c1f7c60dc396e9e5b' 
  AND token = 'XW/4Reakj/C39wlMR4dTpT+01MiEvO1ZQ3/Kd9GZzvc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}