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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8223a0c3c8b58377a2c83b71d916c1e645215b30efa2ad6e948b99fc146bb408' 
  AND token = 'MIfMyBZ4UE+CjA6w2+YSVcmXzXR55TejGiawGIrAbp4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}