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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '28d64e1b70833a1209ce9aa8c049ff77e269b3300dadabf163d69f1e26765c01' 
  AND token = 'S1leM9XPa4HN09Zy64ZAA/WHMNYzvB8qw0HyCYg/JDY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}