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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a2ce379d5dc80b581f93730d28794f5f787b011a818d1d8b91750ca20551ed88' 
  AND token = 'bX+dNOPccWU5PrE5gE4sHhaPDKk3peYuZ7GQqEMsy6c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}