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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '48bf180e2bf720d33c952374ed466be3544721f2e29d594d36b29202f3eb1dbc' 
  AND token = 'lpoB2o1AWDtkxLogmxyUGxSaFA+ZsowBBb3wKQuwGoM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}