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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'aef9a76b06868574f60c402bc1f1af10cd0664a5608c6388673e85a97931b5c4' 
  AND token = 'JkzR27A14KJvxhIScwC4OYtTXNtPLNhveVAUzSo9cFM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}