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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5078a2982b23ab1e466231a734a261249f1f4d2b9a27d3820a3e92364f773dbf' 
  AND token = '3Xa4JmpdAnbQxTXWrOl65NjkepWtybJXattY0sbO5PE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}