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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd53e933bd96f3187b71fc816a03b3fff39cdd4178b52ab6a379d68ee9c8ac590' 
  AND token = '8sJxqN3k3fMlb6LEHV8YGMsuN0+2xDCmzAv9d4R/TV0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}