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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '41f021c74053f2dded7443bbae93f39f4481cae8d7c33c98d099d41bb5b50273' 
  AND token = 'k6Mgea1r+KUW8QN2j96yYYhKRZrDRcFINkTHCRRs3Mg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}