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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '349c0f20b274eaed59985e4731bd0a5fa7a91277f77650e61b93dbbc2cc90a5c' 
  AND token = 'N1NmsgqoOHeUN1426OweAvHW3mS7uD3qpw2HXNW1qEg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}