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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9bc7e7298b8f27e2dbdcceb2dcb226d48a13cae99a0c082b6d68017a10980cd9' 
  AND token = 'u/PUoO1LyG4VmKnfVyvC0uoiaHdcLrcHwM+DFKdAvfs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}