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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c4b13df845859f8cb643be366108ff06990af90681c475ec36ebc2e9e72b5b88' 
  AND token = 'biL0SfWEWRI8jCwSeNFpWimeoyGasn6xAuG+JzXbiN4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}