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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2d220d6b4edea4fa206264793cab22ac77f0b05fc5f9c3897a0f88d02760d389' 
  AND token = 'tS3C4S6GU5NIo8XZHzzANuynUl+THxM2mG+vVl51OzA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}