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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1e3946c157986e880f0d64dbc58afdccb45bbc8d28c2fab2e91e0531e1e5c987' 
  AND token = 'N0w4RDNhTpNwq6jnzMBI9v7qX+XbaFS+zDHZzmN1a+U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}