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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2822a1be53a431ea1a04b141c3f9ed3e2c0985aa209d56be43c41c67633fd8f2' 
  AND token = 'ZQ2K6KMdki4SvlMmpLHR3f2zj0zquiUTFUM3rtG0T4k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}