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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ef404f9e376eee8ef1fbd91699e5aa4813524da62da6479a1261d36f1711b101' 
  AND token = 'u1jHUB4LVsHYpLS4fHGCwQrMnSlhJWPT6IT7t+5p91o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}