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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '378ee3910635d4179f97bf31cdf22cb0453a78a049d69a0a268f2a47512ce8ae' 
  AND token = '391AotAxSec+GiVVt6Cei9mNdHZvMAG5UcGddtVQ8mY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00036

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}