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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '44ba354096e21a6566e17c3a447e5c2e9ccd849ad5f33dccbffb46811d0f6639' 
  AND token = 'AysDnrkWwoXkUSKbmOWjcWiPW+ugA3ti5RT1XUaF2z0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}