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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '48452c619ddd3227e88b810e4aafa3c04700a2712500034698cd0bb7b780e8cc' 
  AND token = 'v/IS52yImnf5Dn/EL0NW9nnqPtgRtmtwFXbGUA+gwFE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00047

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}