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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5ce3d1b8a5417d8a3ef511fe0b0be377a14988cd92a25b98acc8b85afd33a497' 
  AND token = '/2FvLwvqpwpY9z4R6x4uWjQ3DfU6lvGG3ub856Urr00=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}