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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '100f74bff74e26244dcbbc78957e71ab256756a15b5977f6dd7cf5b9030e550e' 
  AND token = '6XD9Pw4E6NcEX9+Sf3MwEf45dVXvQ6iDHfICBV7p3RQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}