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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2eccf27728764b6f6cfa4fa7771f5143699b05bcd94918b065b193539e67042b' 
  AND token = 'C7F8zRGNlFutbG1CB1oDwmXnAA0TntlSv1DVAERkErc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}