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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80734dbe73bd69147939e49880384a70ada46dfe674836c6899653a06926f92f' 
  AND token = 'ZJq7u8dfyjALBs2lsx8QbfpxSRhrnFXJpdHxGurh2ME=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}