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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0c4134fcb986aa4dfaedd13fe436c4ab04e18240565f7a143d8b78aa25592f07' 
  AND token = 'JtnZBV2O3ZHlPnrEUwnnmhNLIomE9XAS3QrNwYZUBe4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}