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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6f7cf5d0d70bd525efb7ea8a94506edd5575637dc26edde2d5d6ce0f7316c378' 
  AND token = 'DH+3LCjZNbITrFdhl3XNvRoGTUx+Z4Y9IRej3Inmjjo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}