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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e5646b1cb18bfac0310eae4d89def5e9f9d189d11b4c75852e922e127271e1d4' 
  AND token = 'luj7KBY3oN2ngTwHHv0TxUH0tFKYR5HSa8IgzsNagbQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}