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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4b2272c3cfac4d25379c8bb46c16a996f78d9a0889fd7d98c0242f92729eab56' 
  AND token = '6REBBmvyVH7pp3aNG+TsjPwUIEbpcW0mkbVqoPuM2Gw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}