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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '589ea2cd66331c51b36084a2679df336b6cbc5f47d7ccbf5894fc380d124b3f2' 
  AND token = 'Wi5haUekXcuBMFNBNBJs43vIKTh3UpSUGnilBhbtagw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}