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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5f9578f46df84c5f40b6241d40810b2c0ed95bae4cc595def88e5725e3366beb' 
  AND token = 'Yn8/WN0umcLgInh/C7dpFGpHQrxcVzzq5tFO2ewRAtQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}