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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e97d21146ca686ecbb126efc1456b186fa584b4b4da6c6f8a8a7c3be5f206dca' 
  AND token = '5r51TRh4AOAiQCpDn0brB8jrE+DA0GYtRdhhYRetiAo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}