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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '110161755c246be5da8de0afd066d59dbf4a480bdb195fd4a55da823ba3073f9' 
  AND token = 'PfKOerh5nH0+MZzNbQPazYyXQLTTnshy8wu9N8kePgw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}