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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2ab49d152aafd17604c7225a191f92db5fbd4bf44ce376b600d59c754c8faeae' 
  AND token = '8PItyz5w2QPum1d2YpB+vZENFf+WWt691bUGbyjq01M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00054

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}