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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '645a411dc648ef133116242c8c0b8c5b355f88fa372017da539ad519ca2b5d11' 
  AND token = 'tIV2+PORKihACsvRgOt3NtPxSZVngO9SFPwT9BoB16o=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00039

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}