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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '249a318f3fb807817fb77797e87bdad2f32f6d78708a2c924640ea741046019f' 
  AND token = 'mlbpA1/d2e78z5eD1VKyajkCBGlL8I+RipFM2/hOKwk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}