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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '51c0152b01b2a262a917a3b3090084d63d58dc123d25ed9721eaad7e43ab3b4f' 
  AND token = 'zboUk0BhhGoa/D9jCh0uefJTBDetqW0vpFIqu36PqyM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}