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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8b5629ed6f653cf6c2325d840d9905bfee63097ed6495ca1862d9cebfe4b5b43' 
  AND token = 'npV/Yb2+YXJgoJBERnmSD8gDB3p0a5m4phVxv9V8aBk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}