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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0cc66886ff5b2e60d29a4357847b34b0db4df6f00827250dd5036b9b519b6721' 
  AND token = '2DWMvx9qsHdfns6/XYmlbVnTbTAUmn7fu7vZYTfNwJQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}