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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '02271f1b10f3e1f5226fbc59044c0a35d407112f32a02825b9dc04c249e24d2d' 
  AND token = 'X+bNAOTUcbcnhb5kNPKQuTaBOJfl4IjUp7ofLwI/nhU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}