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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1f0daed0fd31c7f58d7ec50f3e5d728b7a3f7c4f7a4a3c37b5e07253290c5c94' 
  AND token = '4PshvCEPF2g0D40o/qhwVosSzHwurmxTZb9Pex+OcTg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}