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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1e78256c07f3c610876988a1749b60c82fb2006f59d9a554c264440adc65f626' 
  AND token = 'DgIMV0qi5y7eUwx9tv+GU3TiZtjf5A5apP/FaU80fds=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}