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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '437489bd742000ff85199fb8c44d3dbfc9a3b05d72bfd81e55e889838cac98ee' 
  AND token = 'Yt1YiwHnuNKdZyPGr2TGxd2EJKbV1SxHAlhUcuCR6do=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}