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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1e916040d2bc304ee19c4f1b56a18dc963c788d80bde135f31229c1de6095c93' 
  AND token = '/Uw1WcYzTEoxb0xK5RR0FWvfzKKZDEcuvN4/ywbmoYk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}