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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1e3059a10bd00f0ca5bab81f240ddf5b80562b1b93e8667e09c3a3245e3dd9b4' 
  AND token = '/wk543cmAWQiJSs04EbP4zR3RPWaDmtYsVLcuw+Vegc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}