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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '220908330f23fba27cc55d277a40bc456e4c7513ad4d7b41885f3a5ce7f1479c' 
  AND token = 'MVz8iQSNmNFx6DGG09prAM5rUh2F6FpcHTzGZ76lSE8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00042

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}