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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '05b04f2f3eeaaa77d7d6c9646d730a36801c89dee5c5cdfbe0828dbc760d5452' 
  AND token = 'Mzcqpzui9EZmkfVvrNW1dTp1xccrL55nZMTFbn0bq6g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}