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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21167212cfa814720b520e832c9f1e38a52c1668ffee2117adafca9ba15b56a7' 
  AND token = 'c9AyW+ZB3vpmFUmK6pw1YhnYe7X3AWnzW7E00YscLbQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}