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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ec8181e47143bd6791119af16361ef4a326123055632c3cd9ab26635a1ff7189' 
  AND token = 'mMj4AWS2kmUfzsT0h3kPBNdlSyc+Y1PuEcCRxlle9uE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}